Microsoft Excel was developed as a tool for creating spreadsheets for your operations to help you organize your data and perform analysis on that data. Along with this it also provides additional functionalities like graphing tools, calculations, and pivot tables to name a few. Python on the other hand is a programming language developed for easy code readability. It can be used for developing web applications, building machine learning models, and carrying out Exploratory Data Analysis on any given data to extract actionable insights. This article tells you how to set up the Excel Python Integration.

You will learn about the two best methods that you can use to integrate Excel with Python using Python libraries after looking at a brief introduction of Microsoft Excel and Python.  

Introduction to Microsoft Excel

Excel Python integration: Microsoft Excel Logo
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Microsoft Excel was the bedrock of data analysis before technology brought forth more comprehensive tools that made the task of data analysis a lot easier. Microsoft Excel houses a large number of functionalities and along with its ease of use, it has been an integral tool for all manners of education, business, finance, and research to name a few areas. Microsoft Excel continues to be a popular data analysis tool to organize and present large amounts of data. However, with the entry of Python and similar programming languages data analysis has become an entirely different ball game. 

Before going into how Python has changed the landscape for web development, infrastructure management, and data analysis, here is a look at the challenges Microsoft Excel is working to overcome:

  • Syntax Errors: Excel users usually encounter errors when inputting formulas manually, or while copying and pasting data in some cell ranges. 
  • Security Issues: Companies need to be wary of the information that they place in Excel sheets, which makes this data vulnerable to misuse and cyber attacks.
  • Increasing Data Volume: A few years back, data was stored in Excel and operations could be carried out smoothly on this data. But with a monumental increase in data volume, it has become infeasible to keep on storing this data in Excel spreadsheets because it leads to complex analytical issues. This happens because Microsoft Excel is primarily geared towards smaller sets of data. 

Introduction to Python

Excel Python integration: Python logo
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Python initially developed as a general-purpose programming language to automate tedious tasks that developers might face daily. But it has now grown to spearhead the development of a wider data science community, owing to its sheer potential and capabilities. Python can be used for a wide range of applications as discussed before, from developing apps to carrying out Exploratory Data Analysis on customer data to extract actionable insights from it. The shift from Microsoft Excel to Python took place due to the following use cases:

  • Data Mining: You can say, extract data from Twitter, and perform a sentiment analysis on the tweets to identify the percentage of people that may be happy/unhappy with something. You can do the same thing on an eCommerce site like Amazon to find out the feedback for a particular product and gain insightful inputs that can help you improve upon the customer experience.
  • Blockchain Building: You can build a Blockchain using Python that can be used for any kind of financial transaction.
  • Data Automation: You can automate a lot of simple tasks like formatting data, renaming files, spell checking, generation of Microsoft Excel reports using Python for a start.
  • App Building: You can build interactive apps that help you achieve a specific task using Python by leveraging in-built Python libraries in place that offers you countless possibilities.  
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Understanding the Excel Python Integration Setup

To integrate Excel with Python, you can use a few handy Python libraries and start this process. A Python Library is an assortment of methods and functions that let you perform actions without having to write the code for it from scratch. This lends efficiency to the work of a Data Analyst as they can simply import the required libraries. For instance, Google Tensorflow is a Python library that is used for developing machine learning projects. SciKit Learn is a Python library that comes in handy when dealing with complex datasets.  

The two libraries you can use for Excel Python Integration are openpyxl and pandas. The next sections discuss how you can use them in detail. 

Method 1: Using the openpyxl Library for Excel Python Integration

Excel Python integration: Openpyxl for Excel Python Integration
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openpyxl can be used for Excel Python Integration to either extract data from a database into an Excel spreadsheet or convert an Excel spreadsheet to a programmatic format. These are a few use cases where you might need to use openpyxl for Excel Python Integration:

  • Exporting to a Spreadsheet: Given a database table where you store all customer information. This information will be required by the Marketing team in order to promote new products of the said company. In the absence of access to the database or no-to-minimal SQL knowledge to extract the information, openpyxl can be used to convert this database table into an Excel spreadsheet. 
  • Adding Additional Information to a Spreadsheet: Now for the above example, say you need to add the total amount spent by the customers in your store to your Excel spreadsheet. To perform this, you will have to iterate through the entire spreadsheet, iterate through each row and extract the total amount across the database. This value would then be added to the Excel spreadsheet. 

Here are the steps for using openpyxl for Excel Python Integration:

  • Step 1: First, you need to install the openpyxl package using pip. Write the following command in your terminal:
$ pip install openpyxl
  • Step 2: Once you are done with the installation of openpyxl, you can set up a sample Excel spreadsheet using the following code snippet:
from openpyxl import Workbook
workbook = Workbook()
spreadsheet =
spreadsheet["A1"] = "Hello"
spreadsheet["B1"] = "World!""HelloWorld.xlsx")
  • Step 3: The next step would be to see if you can read the sample spreadsheet you created before, for the Excel and Python Integration. You can use the following code snippet to open it:
>>>from openpyxl import load_workbook
>>> workbook = load_workbook(filename="sample.xlsx")

>>> workbook.sheetnames
['Sheet 1']

>>> spreadsheet =
>>> spreadsheet
<Worksheet "Sheet 1">

>>> spreadsheet.title
  • Step 4: Retrieve data from the Excel spreadsheet using the following code snippet:
>>> spreadsheet["A1"]
<Cell 'Sheet 1'.A1>

>>> spreadsheet["A1"].value

>>> spreadsheet["F10"].value
"G-Shock Men's Grey Sport Watch"
  • Step 5: You can now iterate through the data and begin converting it into a format that can be used for data analysis, which is one of the main objectives of Excel Python Integration. The iteration can be carried out by using a combination of rows and columns for slicing:
>>> spreadsheet["A1:C2"]
((<Cell 'Sheet 1'.A1>, <Cell 'Sheet 1'.B1>, <Cell 'Sheet 1'.C1>), 
 (<Cell 'Sheet 1'.A2>, <Cell 'Sheet 1'.B2>, <Cell 'Sheet 1'.C2>))

This indicates all the spreadsheet data from A1 to C2.

  • Step 6: The next use case of Excel Python Integration discussed was appending data to the existing Excel spreadsheet. Here is the code snippet to add some data to the sample spreadsheet created in the second step:
from openpyxl import load_workbook
# Begin by opening the spreadsheet and selecting the main sheet 
workbook = load_workbook(filename="hello_world.xlsx")
spreadsheet =
# Enter what you want into a specific cell
spreadsheet["C1"]="Manipulating_Data ;)"
# Save the spreadsheet"hello_world_append.xlsx"

On opening the document, you will notice that Manipulating_Data has been added to your Excel spreadsheet.   

Method 2: Using the pandas Library for Excel Python Integration

Excel Python integration: Pandas for Excel Python Integration
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You can also use the pandas library for Excel Python Integration. Pandas is the most widely used Python library to interact with Excel files. You can use this library to load data from your Excel spreadsheet and perform key operations like inserting, deleting columns and rows, and appending information if necessary. This Excel Python Integration method is mainly used for Exploratory Data Analysis where you take the data present in the Excel spreadsheets, organize and clean it up, thereby making this data ready for analysis.

Here you will see how to import data from an Excel spreadsheet using pandas:

  • Step 1: Install pandas using pip in your terminal as follows:
$ pip install pandas
  • Step 2: Suppose you have a Microsoft Excel sheet as follows: 
Excel Python integration: Microsoft Excel spreadsheet example
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You can export data from this Excel file to pandas Dataframe using the following code snippet:

Excel Python integration: Code snippet to import Excel sheet with pandas
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You can select columns similar to method 1, by using slicing. You can append a new set of data to a pandas Dataframe by using the dataframe. append() function. Here the dataframe will be replaced by the name of your dataframe. For more information on the same, refer to the pandas documentation.   


This article talks about two simple methods you can use to set up Excel Python Integration for your business operations. It initially talks about Microsoft Excel and Python before delving into Excel Python Integration.

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Content Marketing Manager, Hevo Data

Amit is a Content Marketing Manager at Hevo Data. He enjoys writing about SaaS products and modern data platforms, having authored over 200 articles on these subjects.

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